James J. Hsieh

James J. Hsieh, MD, PhD

Specializes In
  • Medical Oncology
Languages Spoken
  • English
  • Mandarin
  • Taiwanese


Sees Patients For

Kidney cancer, rare kidney cancer, targeted therapy, immunotherapy, precision medicine

Hospital Affiliations

  • Barnes-Jewish Hospital



Academic Title(s)

Professor, Oncology
Division of Medical Oncology
Molecular Oncology & Developmental Therapeutics

Research Interests

Dr. Hsieh founded the Translational Kidney Cancer Research Program (TKCRP) to enable seamless collaboration among basic, preclinical and clinical scientists. The team employs state-of-art platforms and clinical trial materials to integrate kidney cancer genomics, transcriptomics, proteomics, metabolomics, and therapeutics. His group pioneered a novel metabolic analytic algorithm (Metabologram) to interrogate human cancer metabolism in 2016. His laboratory recently established novel kidney cancer mouse models that recapitulate prevalent human kidney cancer mutations. Through studying kidney cancer, Dr. Hsieh proposed a novel cancer evolution (braided cancer river) model in 2015, capitalizing phenotypically, mechanistically convergent events to guide effective cancer therapy and overcome treatment-resistance. His primary translational goals are to develop novel mechanism-based, personalized therapeutics to prevent recurrence in high-risk patients and provide cure to significant number of metastatic kidney cancer patients.

Publications & Research

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Fellowship, Medical Oncology

2003 Dana Farber Cancer Institute, Harvard Medical School, Boston, MA

Fellowship, Medical Oncology

2000 Washington University School of Medicine, St. Louis, MO

Residency, Internal Medicine

1999 Barnes-Jewish Hospital, St. Louis, MO

PhD, Molecular Biology

1996 Johns Hopkins University School of Medicine, Baltimore, MD

Medical Degree

1990 Taipei Medical University, Taipei, Taiwan

Financial Disclosures
  • BostonGene
    • Equity: Yes
    • Reporting Date: 05/01/2022

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