Appointments
Sees Patients For
Lung disease, lung transplant
Hospital Affiliations
- Barnes-Jewish Hospital
Locations
- Center for Advanced Medicine Lung Center4921 Parkview PlaceSt. Louis, MO 63110Suite: BFloor: 8Fax: 314-454-5571Appointments:
Experience
Board Certifications
- Critical Care
- Internal Medicine
- Pulmonary
Academic Title(s)
Professor, MedicineDivision of Pulmonary and Critical Care Medicine
Research Interests
The focus of my clinical research is lung transplantation. I am specifically interested in the development, prevention, and management of chronic allograft dysfunction, or bronchiolitis obliterans syndrome, after lung transplantation. Our group has identified both allo-immune factors such as minimal acute rejection and the de novo development of anti-HLA antibodies, and non-immune variables such as primary graft dysfunction and viral respiratory tract infections as key risk factors for the development of chronic allograft dysfunction. These highlight the complex interactions between the recipient, the allograft, and the environment that result in allograft injury and remodeling leading to physiologic dysfunction. We are currently investigating therapeutic interventions that might uncouple the relationship between these clinical events and chronic allograft dysfunction, including novel immunosuppressive approaches and anti-inflammatory agents.
Publications & Research
View research profile »Education
2003 Pulmonary & Critical Care Medicine, Washington University School of Medicine, St. Louis, Missouri
2000 UT Southwestern Medical Center, Dallas, Texas
1997 University of Texas, Southern Medical Center in Dallas, Dallas, Texas
1992 Chemistry, Southern Methodist University, Dallas, Texas
- Transmedics
- Consulting/Advisory Board: $10,000 - $19,999
- Reporting Date: 05/01/2023
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