Nicole Brossier, MD, PhD

Research Interests

The brain is the most common site for solid tumors to arise in childhood, but we understand relatively little about the factors that drive brain tumor formation in kids. Oncogenic mutation is a necessary but not sufficient part in this process, given the observed presence of oncogenic mutations at relatively high rates in healthy, tumor-free pediatric brains. In the Brossier lab, we are interested in identifying which factors increase the rate of tumorigenesis following oncogenic mutation and the molecular basis underlying this effect, with an eye towards using this information for patient risk assessment and to identify new targets for therapeutic intervention.