Mark H. Hoofnagle, MD, PhD

Specializes In
  • Acute and Critical Care Surgery
  • General Surgery
Languages Spoken
  • English


Sees Patients For

Trauma, emergency and general surgery, surgical critical care; chest wall reconstruction, skin and soft tissue reconstruction, rib and sternal fractures, traumatic injury from blunt and penetrating mechanisms, cholecystitis, appendicitis, necrotizing soft tissue infections, bowel obstruction, mesenteric ischemia, diverticulitis, chronic respiratory failure, feeding access

Hospital Affiliations

  • Barnes-Jewish Hospital



Board Certifications

  • Surgical Critical Care
  • General Surgery

Academic Title(s)

Assistant Professor, Surgery
Division of General Surgery
Section of Acute & Critical Care Surgery

Research Interests

Basic Science: Our ACCS lab studies the physiologic changes in the trauma patient and factors contributing to deep venous thrombosis, acute lung injury and sepsis. I study the interactions between the vasculature and the coagulation system that result in traumatically injured and critically-ill patients being more susceptible to blood clots and venous thromboembolism. Clinical: As part of the ACCS division I perform research evaluating outcomes in trauma patients related to DVT prophylaxis, antibiotics use and transfusion. Research projects include evaluation of outcomes in COVID patients, DVT, surgical site infection, trauma resuscitation and mass transfusion, whole blood and traumatic brain injury. Policy: I study the effects of public policy on the gun violence epidemic, with a focus on the interactions between state laws and gun trafficking, as well as state policies on abortion restriction and maternal mortality.

Publications & Research

View research profile »


Fellowship: Surgical Critical Care and Trauma, Acute Care, and Emergency General Surgery

2018 University of Pennsylvania, Philadelphia

Residency: General Surgery

2016 University of Maryland Medical Center, Baltimore


2009 University of Virginia School of Medicine, Charlottesville

Medical Degree

2009 University of Virginia School of Medicine, Charlottesville