Mark H. Hoofnagle, MD, PhD

Research Interests

Basic Science: Our ACCS lab studies the physiologic changes in the trauma patient and factors contributing to deep venous thrombosis, acute lung injury and sepsis. I study the interactions between the vasculature and the coagulation system that result in traumatically injured and critically-ill patients being more susceptible to blood clots and venous thromboembolism. Clinical: As part of the ACCS division I perform research evaluating outcomes in trauma patients related to DVT prophylaxis, antibiotics use and transfusion. Research projects include evaluation of outcomes in COVID patients, DVT, surgical site infection, trauma resuscitation and mass transfusion, whole blood and traumatic brain injury. Policy: I study the effects of public policy on the gun violence epidemic, with a focus on the interactions between state laws and gun trafficking, as well as state policies on abortion restriction and maternal mortality.